AbstractExperimental cement formulations were prepared by replacing part of the methylmethacrylate (MMA) liquid phase of a conventional surgical cement with an equivalent weight of 2,2‐bis [4(2‐hydroxy‐3‐methacryloxypropoxy) phenyl] propane (Bis‐GMA), which is the reaction product of diglycidyl ether of bisphenol A and methacrylic acid. It was found that up to 50 wt % of the MMA could be replaced by Bis‐GMA without reductions in flow characteristics of the precured polymers. Cements containing 20, 30, 40, and 50 wt % of Bis‐GMA in the liquid component were prepared. Over this range of Bis‐GMA wt %, it was found that, relative to the unmodified cement, the volumetric shrinkage (DV), the peak temperature reached during the polymerization reaction (Tp), and the flexural strength (obtained in three‐point bend tests) were each significantly reduced, the flexural modulus (obtained in three‐point bend tests) increased significantly, the compressive strength increased slightly, while there were no significant effects on any of the other properties determined, namely, degree of conversion of the monomer during the polymerization reaction and the glass transition temperature. The drops in DV and Tp indicate that cements whose liquid monomers are modified using Bis‐GMA hold promise for use in anchoring total joint replacements. The increase in the crosslinking density with increasing amount of Bis‐GMA renders the polymer matrix more brittle. This feature was considered responsible for the reduced flexural strength. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2005