AbstractIn this study, the indentation creep behavior of human enamel was investigated with a nanoindentation system and a Berkovich indenter at a force of 250 mN with one‐step loading and unloading method. A constant hold period of 900 s was incorporated into each test at the maximum load as well at 5 mN minimum load during unloading. The indentation creep at the maximum load and creep recovery at the minimum load was described with a double exponential function and compared with other classic viscoelastic models (Debye/Maxwell and Kohlrausch–Williams–Watts). Indentation creep rate sensitivity, m, of human enamel was measured for the first time with a value of ∼0.012. Enamel displayed both viscoelastic and viscoplastic behavior similar to that of bone. These results indicate that, associated with entrapment of particulates between teeth under functional loading and sliding wear conditions, the enamel may inelastically deform but recover upon its release. This behavior may be important in explaining the excellent wear resistance, antifatigue, and crack resistant abilities of natural tooth structure. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009