Thymocytes are activated by toluene inhalation through the transcription factors NF‐κB, STAT5 and NF‐AT
Copyright policy )Thymocytes are activated by toluene inhalation through the transcription factors NF‐κB, STAT5 and NF‐AT
AbstractToluene has been extensively examined for effects on the central nervous system. To investigate the influence of low‐level inhalation of toluene on the naive immune cells, male C3H/HeN mice were exposed to filtered air (control) and 50 ppm of toluene for 3 weeks. Low‐level exposure resulted in (1) increased proliferation of thymocytes, (2) IL‐2 production induced in thymocytes and (3) activation of the transcription factors NF‐κB, STAT5 and NF‐AT in thymocytes. These results suggest that thymocytes are sensitive cells and T cell activators are candidates for biomarkers for low‐level exposure to toluene on naive immune cells. Copyright © 2010 John Wiley & Sons, Ltd.
Male, Mice, Inbred C3H, Time Factors, Dose-Response Relationship, Drug, NFATC Transcription Factors, T-Lymphocytes, NF-kappa B, Thymus Gland, Lymphocyte Activation, Mice, Administration, Inhalation, STAT5 Transcription Factor, Animals, Interleukin-2, Cells, Cultured, Toluene
Male, Mice, Inbred C3H, Time Factors, Dose-Response Relationship, Drug, NFATC Transcription Factors, T-Lymphocytes, NF-kappa B, Thymus Gland, Lymphocyte Activation, Mice, Administration, Inhalation, STAT5 Transcription Factor, Animals, Interleukin-2, Cells, Cultured, Toluene
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!