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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao The Journal of Clini...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
The Journal of Clinical Pharmacology
Article . 1987 . Peer-reviewed
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Disposition of Famotidine in Renal Insufficiency

Authors: William F. Keane; William F. Keane; John A. Opsahl; John A. Opsahl; Paul A. Abraham; Paul A. Abraham; A. N. Chremos; +5 Authors

Disposition of Famotidine in Renal Insufficiency

Abstract

The disposition of famotidine was evaluated in 18 patients; Group 1, mild renal insufficiency, [creatinine clearance (CLCR): 30–60 mL/min]; Group 2, moderate to severe renal insufficiency (CLCR: 10–30 mL/min); Group 3, end‐stage renal disease requiring maintenance hemodialysis (anuric). Blood and urine samples were obtained over a 72‐hour period. Plasma concentration‐time data demonstrated biexponential decay. The terminal elimination half‐life was prolonged in Group 3 (18.6 ± 5.7 hr) compared with Groups 1 (9.3 ± 2.3 hr) and 2 (9.7 ± 1.7 hr), P < .05. Steady‐state volume of distribution ranged from 0.80 to 1.26 L/kg but did not differ among the groups. Total body clearance (CLP) and renal clearance were significantly lower in Groups 2 and 3 patients compared with Group 1 patients. Nonrenal clearance was not related to CLCR. The CLP correlated well with CLCR (CLP = 1.59 CLCR + 33.8, r = 0.830, P < .05). These data indicate that dosage adjustment may be necessary in patients who have renal insufficiency.

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Keywords

Adult, Male, Middle Aged, Anti-Ulcer Agents, Famotidine, Thiazoles, Creatinine, Humans, Kidney Failure, Chronic, Female, Kidney Diseases, Aged, Half-Life

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    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
28
Average
Top 10%
Top 10%
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