descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1981 English Publisher:WileyJournal:The Journal of Clinical Pharmacology, volume 21, pages 16-19 (issn: 0091-2700, eissn: 1552-4604,

Authors: Richard C. Ursillo; Harbans Lal; Gary T. Shearman;

doi: 10.1002/j.1552-4604.1981.tb01726.x

pmid: 7217339

Nonnarcotic Antidiarrheal Action of Clonidine and Lofexidine in the Rat

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Abstract

Abstract: Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose‐dependent inhibition of diarrhea induced by castor oil treatment in the rat. Both drugs were more potent and longer acting than diphenoxylate. Pre‐ and posttreatment with naloxone (5 mg/kg) failed to prevent or antagonize the antidiarrheal effect of clonidine and lofexidine. These data suggest that clonidine and lofexidine may provide potent antidiarrheal activity of a nonnarcotic nature.

Related Organizations

University of Rhode Island
United States

Keywords

Diarrhea, Male, Narcotics, Animals, Antidiarrheals, Clonidine, Rats

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