Hypoxia‐inducible factor 1 and cancer pathogenesis
Copyright policy )Hypoxia‐inducible factor 1 and cancer pathogenesis
AbstractHypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increase O2 availability by stimulating angiogenesis or that reprogram cellular metabolism to adapt to reduced O2 availability. Proof of principle studies in mouse models suggests that inhibition of HIF‐1 activity may have therapeutic effects, especially in combination with other anticancer drugs. © 2008 IUBMB IUBMB Life, 60(9): 591–597, 2008
- Johns Hopkins University School of Medicine United States
- Johns Hopkins Medicine United States
Oxygen, Proto-Oncogene Proteins c-myc, Glucose, Von Hippel-Lindau Tumor Suppressor Protein, Neoplasms, Animals, Homeostasis, Humans, Hypoxia-Inducible Factor 1, Energy Metabolism, Reactive Oxygen Species, Carcinoma, Renal Cell
Oxygen, Proto-Oncogene Proteins c-myc, Glucose, Von Hippel-Lindau Tumor Suppressor Protein, Neoplasms, Animals, Homeostasis, Humans, Hypoxia-Inducible Factor 1, Energy Metabolism, Reactive Oxygen Species, Carcinoma, Renal Cell
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