Mammalian ceramide synthases
Copyright policy )Mammalian ceramide synthases
AbstractIn mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and their structure and intracellular localization. Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases. © 2010 IUBMB IUBMB Life, 62(5): 347–356, 2010
Sphingosine, Neoplasms, Tumor Suppressor Proteins, Sphingosine N-Acyltransferase, Animals, Humans, Membrane Proteins, Gene Expression Regulation, Enzymologic
Sphingosine, Neoplasms, Tumor Suppressor Proteins, Sphingosine N-Acyltransferase, Animals, Humans, Membrane Proteins, Gene Expression Regulation, Enzymologic
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