The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia
Copyright policy )The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia
AbstractThe discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of involved patients because they change the nature of malignancies in different ways like mediating therapeutic resistance; therefore, studying these gene/pathways is essential. This review aims to discuss SF3B1 and NOTCH1 roles in the pathogenesis of various types of leukemia and the therapeutic potential of targeting these genes or their mutations to provide a foundation for leukemia treatment.
- Karolinska Institute Sweden
- Tabriz University of Medical Sciences Iran (Islamic Republic of)
- Alborz University of Medical Sciences Iran (Islamic Republic of)
- Bushehr University of Medical Sciences Iran (Islamic Republic of)
- Bam University of Medical Sciences Iran (Islamic Republic of)
Leukemia, Mutation, QW Microbiology and Immunology, Humans, RNA Splicing Factors, Receptor, Notch1, Phosphoproteins, Transcription Factors
Leukemia, Mutation, QW Microbiology and Immunology, Humans, RNA Splicing Factors, Receptor, Notch1, Phosphoproteins, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!