GATA‐3 in T‐cell lymphoproliferative disorders

descriptionPublicationkeyboard_double_arrow_right Article 17 Jul 2019 United States English Publisher:WileyJournal:IUBMB Life, volume 72, pages 170-177 (issn: 1521-6543, eissn: 1521-6551,

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Authors: Carlos Murga‐Zamalloa; Ryan A. Wilcox;

doi: 10.1002/iub.2130

pmid: 31317631

pmc: PMC7184638

handle: 2027.42/152971

GATA‐3 in T‐cell lymphoproliferative disorders

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Abstract

AbstractGATA‐3 regulates the differentiation, proliferation, survival, and function of peripheral T cells and their thymic progenitors. Recent findings, reviewed here, not only implicate GATA‐3 in the pathogenesis of molecularly, genetically, and clinically distinct T‐cell lymphoproliferative disorders, but also have significant diagnostic, prognostic, and therapeutic implications.

Country

United States

Related Organizations

University of Michigan–Ann Arbor
United States
University of Michigan
United States
University of Michigan–Flint
United States

Keywords

PTCL, Science, T-Lymphocytes, Ecology and Evolutionary Biology, Cell Differentiation, GATA3 Transcription Factor, Lymphoproliferative Disorders, CTCL, Tâ ALL, Mutation, Humans, GATAâ 3

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