ABSTRACT Salmonella, a gram‐negative bacterium from the Enterobacteriaceae family, is widely distributed in nature. To date, over 2600 serotypes have been identified. Salmonella enterica serovar Kentucky (S. Kentucky) is considered to be a “super‐resistant” strain of Salmonella in Europe and the USA and is a rare serotype in China. Clinical isolates are typically obtained from patients’ fecal samples, with no previous reports of isolation from the eyes. Here, we report a case of isolation of S. Kentucky from the purulent aspirate of an orbital abscess during routine clinical practice. The infection was successfully managed by surgical excision of the primary lesion in combination with targeted antibiotic treatment. This case thus emphasizes the need for clinicians to select antibiotics based on antimicrobial susceptibility reports.