The IGF‐1 receptor in cancer biology
Copyright policy )The IGF‐1 receptor in cancer biology
AbstractThe type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF‐1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy. © 2003 Wiley‐Liss, Inc.
- Kimmel Cancer Center United States
- Temple University United States
- Thomas Jefferson University United States
Apoptosis, Phosphoproteins, Receptor, IGF Type 1, Mice, Cell Transformation, Neoplastic, Insulin-Like Growth Factor II, Neoplasms, Insulin Receptor Substrate Proteins, Animals, Humans, Insulin-Like Growth Factor I, Cell Division
Apoptosis, Phosphoproteins, Receptor, IGF Type 1, Mice, Cell Transformation, Neoplastic, Insulin-Like Growth Factor II, Neoplasms, Insulin Receptor Substrate Proteins, Animals, Humans, Insulin-Like Growth Factor I, Cell Division
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