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Immunity, Inflammation and Disease
Article . 2023 . Peer-reviewed
License: CC BY
Data sources: Crossref
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PubMed Central
Article . 2023
License: CC BY
Data sources: PubMed Central
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Cord blood antibodies following BBIBP‐CorV (Sinopharm) vaccination during pregnancy

Authors: Sedigheh Hantoushzadeh; Nasim Eshraghi; Sarang Younesi; Mohammadreza Salehi; Nima Rezaei; Mohammad Mehdi Hasheminejad; Pegah Rashidian; +3 Authors

Cord blood antibodies following BBIBP‐CorV (Sinopharm) vaccination during pregnancy

Abstract

AbstractObjectiveThis study aimed to evaluate the maternal and umbilical cord blood antibody levels, after COVID vaccination during pregnancy.MethodThe women who received the COVID‐19 vaccine (Sinopharm) during pregnancy were included. Maternal and cord blood samples were tested to detect the severe acute respiratory syndrome coronavirus 2 receptor binding domain (RBD) specific antibodies. In addition, obstetric information and side effects after vaccination were gathered.ResultA total of 23 women were included. Eleven pregnant women took two doses and 12 cases received a single dose of the vaccine. No IgM antibody was detected in any maternal blood or cord blood samples. The RBD‐specific Immunoglobulin G (IgG) antibody was positive in mothers receiving 2 doses of the vaccine and their infants. But the antibody titers were under the positive cut‐off threshold for the other 12 women who were vaccinated with a single dose. Women who received both doses of vaccine had significantly higher IgG levels than a single dose of Sinopharm (p = .025). The same result was demonstrated in infants born to these mothers (p = .019).ConclusionThere was a significant correlation between maternal and neonatal IgG concentrations. Although, receiving both doses of the BBIBP‐CorV vaccine (not 1 dose) during pregnancy is highly beneficial for increasing humoral immunity for the mother and fetus.

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Keywords

COVID-19 Vaccines, maternal mortality, Vaccination, Infant, Newborn, Infant, COVID-19, Original Articles, Iran, RC581-607, Antibodies, Viral, Fetal Blood, Vaccines, Inactivated, COVID‐19, Pregnancy, antibody, Immunoglobulin G, cord blood, Humans, Female, pregnancy, Immunologic diseases. Allergy, Pregnancy Complications, Infectious

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Top 10%
Average
Top 10%
Green
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