AbstractThe Soret and Dufour cross‐diffusion on the electrokinetic flow of Jeffrey fluid augmented with peristalsis have been presented. The fundamental equations are employed to predict the mass distribution in the two‐dimensional asymmetric electroosmotic channel. Reliable approximations such as low Peclet, low Reynolds, and large wavelength are utilized. The analytical solutions of the concentration, temperature, velocity, and stream function are obtained. To predict the effects of prominent parameters such as fluid parameter, electroosmotic parameter, Brinkman, Soret, and Schmidt number graphs are plotted. The phenomenon of trapping is also discussed to observe the behavior on streamlines. It is observed that the electroosmotic parameter enhances the temperature profile. With the increase in Jeffrey fluid parameter, the Nusselt number is decreased. Furthermore, the concentration is decreased with the elevation in Soret and Schmidt numbers. The current study can help reduce the conversion stages necessary for the integration of the low voltage output in an electrokinetic biomass process.