AbstractBackground and AimsDisease X represents the possibility that an unidentified infection may spread globally and start a pandemic. This study explored various aspects of emerging non‐polio enteroviruses (NPEVs) as a possible source of “Disease X,” an enigmatic agent declared by the World Health Organization, and discussed the potential impact of NPEVs on global public health.MethodsIn this perspective article, we collected information from publicly available sources such as Google Scholar, PubMed, and Scopus. We used NPEVs, viral diseases, pandemics, and zoonotic diseases as keywords. We extracted information from the most relevant articles.ResultsNotable outbreaks caused by NPEVs include enterovirus D68 (EV‐D68) and enterovirus A71 (EV‐A71), among many others. With a focus on therapeutic and preventative components, alternate modes of therapy, and the development of broad‐spectrum antivirals, this analysis looks at the origin, epidemiology, genetic alterations, transmission dynamics, and disease pathophysiology of NPEVs. The information presented in the review indicates the current risk assessment of NPEVs, taking into account the following factors: the need for research and therapeutic interventions, the diversity of clinical manifestations, the impact of genetic variability on virulence, the persistence of emergence despite vaccination efforts, recurrent outbreaks, and the global impact of these viruses.ConclusionThere is a possibility that NPEVs could trigger global pandemics based on their zoonotic origins and urges for complete readiness, continuous research, cooperation, and a comprehensive strategy to combat emerging infectious diseases in a constantly changing global environment. It is peak time to acknowledge how important it is to abide by safety and health laws to prevent these illnesses.