AbstractA phytochemical investigation of the resin of Toxicodendron vernicifluum resulted in the isolation of two new sesquiterpenoids, toxicodenanes D (1), endowed with a new carbon skeleton, and E (2), along with six known sesquiterpenoids (Fig. 1). Their structures were determined by spectroscopic analysis, including 1D‐ and 2D‐NMR and mass spectrometry.