Synthesis of 1,2,3‐Triazole Analogues of Lincomycin
Copyright policy )Synthesis of 1,2,3‐Triazole Analogues of Lincomycin
AbstractIn search for new antibiotics we replaced the amide moiety of lincomycin 1 by a 1,2,3‐triazole ring. The 1,2,3‐triazoles 10a–10k were obtained as single regioisomers by ‘click reaction’ of azide 5 with the alkyne 9k, derived from propyl hygric acid, and the alkyl, aryl, or cycloalkyl alkynes ribosomes 9a–9j. The new analogues proved inactive towards wild‐type and A2058G mutant.
- Laboratory of Organic Chemistry Switzerland
- ETH Zurich Switzerland
- University of Zurich Switzerland
1303 Biochemistry, 10179 Institute of Medical Microbiology, 1503 Catalysis, 1604 Inorganic Chemistry, 3002 Drug Discovery, Organic Chemistry, 610 Medicine & health, Biochemistry, Catalysis, Inorganic Chemistry, Drug Discovery, 570 Life sciences; biology, Physical and Theoretical Chemistry, 1606 Physical and Theoretical Chemistry, 1605 Organic Chemistry
1303 Biochemistry, 10179 Institute of Medical Microbiology, 1503 Catalysis, 1604 Inorganic Chemistry, 3002 Drug Discovery, Organic Chemistry, 610 Medicine & health, Biochemistry, Catalysis, Inorganic Chemistry, Drug Discovery, 570 Life sciences; biology, Physical and Theoretical Chemistry, 1606 Physical and Theoretical Chemistry, 1605 Organic Chemistry
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