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Hippocampus
Article
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Hippocampus
Article . 2009 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
Hippocampus
Article . 2010
Data sources: Europe PubMed Central
https://dx.doi.org/10.1002/hip...
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Dynamic up‐regulation of prodynorphin transcription in temporal lobe epilepsy

descriptionPublicationkeyboard_double_arrow_right Article 12 May 2009 English Publisher:WileyJournal:Hippocampus, volume 19, pages 1,051-1,054 (issn: 1050-9631, eissn: 1098-1063, Copyright policy )
Authors: Susanne, Pirker; Elisabeth, Gasser; Thomas, Czech; Christoph, Baumgartner; Elisabeth, Schuh; Martha, Feucht; Klaus, Novak; +2 Authors

doi: 10.1002/hipo.20633

pmid: 19437412

pmc: PMC3073604

Dynamic up‐regulation of prodynorphin transcription in temporal lobe epilepsy

Abstract

AbstractDynorphin neuropeptides are believed to act as endogenous anticonvulsants, though direct evidence for such a role in humans is sparse. We now report pronounced increases of prodynorphin mRNA expression in the dentate gyrus of patients with temporal lobe epilepsy in comparison to controls. We detected a conspicuously right skewed, bimodal distribution of mRNA levels among patients, suggestive of a dynamic up‐regulation of prodynorphin expression in epilepsy. Highest transcript levels were seen postictally. Our data argue for an essential role of dynorphin in the termination of seizures. © 2009 Wiley‐Liss, Inc.

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Keywords

Adult, Aged, 80 and over, Male, Carbon Isotopes, Polymorphism, Genetic, Adolescent, Genotype, Diprenorphine, Enkephalins, Middle Aged, Epilepsy, Temporal Lobe, Child, Preschool, Postmortem Changes, Dentate Gyrus, Humans, Female, RNA, Messenger, Protein Precursors, Child, Aged

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Average
Average
Top 10%
bronze
Related to Research communities
Neuroscience