Comment to "Hepatitis B virus infection and decreased risk of nonalcoholic fatty liver disease: A cohort study." The study by Joo et al. is important in promoting our understanding of the pathogenesis and risk factors of NAFLD. However, additional studies are needed to further explore the link between liver steatosis, hepatotropic viruses, and cardiometabolic risk and to strengthen the notion that fatty liver is a trigger and an amplifier of cardiometabolic risk and a major modulator of infection with hepatotropic viruses.