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Claim

Salvage treatment after covalent BTKi failure: An unmet need in clinical practice in Waldenstrom macroglobulinemia

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2025 Italy English Publisher:WileyJournal:HemaSphere, volume 9 (issn: 2572-9241, eissn: 2572-9241, Copyright policy )
Authors: Anna Maria Frustaci; Arianna Zappaterra; Andrea Galitzia; Andrea Visentin; Michele Merli; Rita Rizzi; Isacco Ferrarini; +23 Authors

doi: 10.1002/hem3.70094

pmid: 39981189

pmc: PMC11841198

handle: 11562/1162253 , 11577/3547737 , 11585/1007111 , 2318/2103871 , 11586/532881

Salvage treatment after covalent BTKi failure: An unmet need in clinical practice in Waldenstrom macroglobulinemia

Abstract

Our findings provide a snapshot of the current therapeutic landscape in WM after cBTKi failure. Importantly, although none of the baseline disease characteristics influenced response to cBTK‐S, the sample size is too small to make any powered evaluation. On this basis, there is an urgent need for approval in this setting. Prospective clinical trials with other targeted agents, immunotherapies, and cellular therapies are currently ongoing in cBTKi‐exposed patients to address this therapeutic gap

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Italy
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Keywords

Letter, 610, Diseases of the blood and blood-forming organs, Salvage treatment, BTKi failure, unmet need, Waldenstrom macroglobulinemia, RC633-647.5, N.D, Waldenström's macroglobulinemia

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 1
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
gold