VEGFR‐2 is downregulated in sestamibi‐negative parathyroid adenomas
Copyright policy )VEGFR‐2 is downregulated in sestamibi‐negative parathyroid adenomas
AbstractBackgroundThe purpose of this study was to determine the expression profile of several biomarkers in sestamibi‐positive (n = 23) and sestamibi‐negative (n = 6) parathyroid adenomas.MethodsA tissue microarray of parathyroid adenomas from 29 patients was constructed and slides were stained for several proteins involved in angiogenesis, inflammation, cell adhesion, cell cycle, apoptosis, and with markers of the sonic hedgehog, mTOR, Forkhead box O and WNT signal transduction pathways. Protein expression was determined using an image‐analysis software (Spectrum Plus©, 38 Aperio).ResultsProtein expression analysis revealed that the vascular endothelial growth factor receptor 2 (VEGFR2) score was significantly higher in the sestamibi‐positive cohort compared to sestamibi‐negative adenomas (P = .038). Other proteins were not differentially expressed between sestamibi‐positive and sestamibi‐negative adenomas.ConclusionIt is hypothesized that VEGFR‐2 overexpression in parathyroid adenomas increases vascular permeability resulting in a higher uptake of sestamibi.
- University of Toronto Canada
- Medical University of Vienna Austria
- Princess Margaret Cancer Centre Canada
- Vienna General Hospital Austria
- University Health Network Canada
Male, Technetium Tc 99m Sestamibi, Neovascularization, Pathologic, TOR Serine-Threonine Kinases, Down-Regulation, Middle Aged, Sensitivity and Specificity, Vascular Endothelial Growth Factor Receptor-2, Cohort Studies, Gene Expression Regulation, Neoplastic, Parathyroid Neoplasms, Reference Values, Humans, Female, Neoplasm Invasiveness, Radiopharmaceuticals, Radionuclide Imaging, Aged, Neoplasm Staging, Signal Transduction
Male, Technetium Tc 99m Sestamibi, Neovascularization, Pathologic, TOR Serine-Threonine Kinases, Down-Regulation, Middle Aged, Sensitivity and Specificity, Vascular Endothelial Growth Factor Receptor-2, Cohort Studies, Gene Expression Regulation, Neoplastic, Parathyroid Neoplasms, Reference Values, Humans, Female, Neoplasm Invasiveness, Radiopharmaceuticals, Radionuclide Imaging, Aged, Neoplasm Staging, Signal Transduction
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