Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi‐institutional cohort
Copyright policy )Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi‐institutional cohort
AbstractBackgroundBetween the publication of the Union of International Cancer Control staging system (UICC) 7th and 8th editions, other staging algorithms for oropharyngeal squamous cell carcinoma (OPSCC) were proposed from Radiation Therapy Oncology Group (RTOG), MD Anderson Cancer Center (MDACC), and Yale University.MethodsWith C‐statistics, the above‐mentioned five staging algorithms were compared for overall and relapse‐free survival endpoints in a multi‐institutional cohort of OPSCC cases (n = 338) treated with primary surgery.ResultsPathological UICC 8th ed yielded the highest C‐indexes in the entire cohort and in the HPV− subset, whereas MDACC was superior for HPV+ OPSCC. RTOG was the simplest and holistic algorithm with a noninferior discriminatory power.ConclusionUICC 8th ed, MDACC, and RTOG offer moderate and comparable efficacy for staging in this OPSCC patient cohort undergoing surgical treatment. Notable discrepancy between clinical and pathological UICC 8th ed algorithms poses potential concerns in diagnosis, treatment, research, and data management.
- University of Bern Switzerland
- University of Zurich Switzerland
- University of Lausanne Switzerland
- University Hospital of Zurich Switzerland
- Unisanté - Centre universitaire de médecine générale et santé publique Switzerland
Male, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, Risk Assessment, Disease-Free Survival, surgery, Cohort Studies, Pharyngectomy, 10049 Institute of Pathology and Molecular Pathology, Cause of Death, Humans, Neoplasm Invasiveness, human papillomavirus, 610 Medicine & health, Papillomaviridae, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Academic Medical Centers, cancer staging, Biopsy, Needle, Papillomavirus Infections, oropharynx cancer, Prognosis, Survival Analysis, Immunohistochemistry, Oropharyngeal Neoplasms, 2733 Otorhinolaryngology, Carcinoma, Squamous Cell, head and neck cancer, Female, Switzerland
Male, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, Risk Assessment, Disease-Free Survival, surgery, Cohort Studies, Pharyngectomy, 10049 Institute of Pathology and Molecular Pathology, Cause of Death, Humans, Neoplasm Invasiveness, human papillomavirus, 610 Medicine & health, Papillomaviridae, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Academic Medical Centers, cancer staging, Biopsy, Needle, Papillomavirus Infections, oropharynx cancer, Prognosis, Survival Analysis, Immunohistochemistry, Oropharyngeal Neoplasms, 2733 Otorhinolaryngology, Carcinoma, Squamous Cell, head and neck cancer, Female, Switzerland
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