Risk of third and fourth tumors in patients with head and neck cancer
Copyright policy )Risk of third and fourth tumors in patients with head and neck cancer
AbstractBackgroundThe objective of our study was to analyze the incidence and location of second and subsequent tumors in patients after an index head and neck carcinoma.MethodsA retrospective study was made by reviewing clinical data prospectively collected from 3631 patients with head and neck cancer. Incidence, location, and histology of the second, third, and fourth tumors was evaluated.ResultsDuring the follow‐up, 839 second tumors, 147 third tumors, and 35 fourth tumors were diagnosed. The annual hazard ratio was 3.8% for second tumors, 5.1% for third tumors, and 7.8% for fourth tumors. The risk of second and subsequent neoplasms remained constant throughout the follow‐up. There were significant differences in the risk of appearance between the second and third tumors (p < .0001), and between the third and fourth tumors (p = .005).ConclusionPatients with a second tumor after an index head and neck carcinoma have an increased risk for developing subsequent tumors. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
- Hospital de Sant Pau Spain
Male, Carcinoma, second primary neoplasm, Neoplasms, Second Primary, Middle Aged, Disease-Free Survival, aerodigestive tract carcinomas, Head and Neck Neoplasms, subsequent neoplasms, Humans, head and neck cancer, Female, Neoplasm Metastasis, carcinogenesis, Aged, Follow-Up Studies, Retrospective Studies
Male, Carcinoma, second primary neoplasm, Neoplasms, Second Primary, Middle Aged, Disease-Free Survival, aerodigestive tract carcinomas, Head and Neck Neoplasms, subsequent neoplasms, Humans, head and neck cancer, Female, Neoplasm Metastasis, carcinogenesis, Aged, Follow-Up Studies, Retrospective Studies
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