Preclinical models of HPV+ and HPV− HNSCC in mice: An immune clearance of HPV+ HNSCC
Copyright policy )Preclinical models of HPV+ and HPV− HNSCC in mice: An immune clearance of HPV+ HNSCC
AbstractBackground.To investigate whether human papilloma virus (HPV)‐specific immune mechanisms can result in tumor clearance, we have created HPV+ and HPV− tonsil cells that form squamous cancers in immune‐competent mice. Here, we determine that an immune‐specific response can clear HPV+ tumor cells and the cellular requirements to mediate this tumor clearance.Methods.Through the benefit of this model, we use in vitro and in vivo methods to better understand how HPV+ cells are rejected.Results.The data show that an in vivo antigen‐specific antitumor response is generated to HPV+ transformed cells and that this response requires CD4+ and CD8+ cells to mount this antitumor response.Conclusion.The findings from this preclinical model will have implications not only in understanding human disease but also as a valuable model for testing immunotherapeutic strategies for HPV+ head and neck cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
- Purdue University System United States
- DePaul University United States
- University of Iowa United States
- Purdue University West Lafayette United States
- Indiana University United States
CD4-Positive T-Lymphocytes, Human papillomavirus 16, CD8-Positive T-Lymphocytes, Adoptive Transfer, Tumor Burden, Mice, Inbred C57BL, Disease Models, Animal, Mice, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Animals, Antigens, Viral
CD4-Positive T-Lymphocytes, Human papillomavirus 16, CD8-Positive T-Lymphocytes, Adoptive Transfer, Tumor Burden, Mice, Inbred C57BL, Disease Models, Animal, Mice, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Animals, Antigens, Viral
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