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pmid: 8586462
AbstractPlatelet‐derived growth factor (PDGF) is a 30 kDa protein consisting of disulfide‐bonded dimers of A‐ and B‐chains. PDGF receptors are of two types, α‐ and β‐receptors, which are members of the protein‐tyrosine kinase family of receptors. The receptors are activated by ligand‐induced dimerization, whereby the receptors become phosphorylated on tyrosine residues. These form attachment sites for signalling molecules, which inter alia activate the Ras · Raf pathway. PDGF has important functions in development and is required for a proper timing of oligodendrocyte differentiation. The v‐sis oncogene of simian sarcoma virus (SSV) is a retroviral homolog of the B‐chain gene, and induces transformation by an autocrine activation of PDGF receptors at the cell surface. SSV induces malignant glioma in experimental animals, suggesting a role for autocrine PDGF in glioma development. PDGF and PDGF receptors are frequently coexpressed in human glioma cell lines. Specific and nonspecific PDGF antagonists block the growth of some glioma cell lines in vitro and in vivo, suggesting that autocrine PDGF is involved in transformation and tumorigenesis. In situ studies of human gliomas show overexpression of α‐receptors in glioma cells of high‐grade tumors. In a few cases, overexpression is caused by receptor amplification. Since high‐grade glioma cells also express the PDGF A‐chain, an autocrine activation of the α‐receptor may drive the proliferation of glioma cells in vivo. © 1995 Wiley‐Liss, Inc.
Platelet-Derived Growth Factor, Cell Transformation, Neoplastic, Brain Neoplasms, Tumor Cells, Cultured, Humans, Receptors, Platelet-Derived Growth Factor, Glioma, Oncogenes
Platelet-Derived Growth Factor, Cell Transformation, Neoplastic, Brain Neoplasms, Tumor Cells, Cultured, Humans, Receptors, Platelet-Derived Growth Factor, Glioma, Oncogenes
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 195 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 1% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |