An association of silicified spicules of hexactinellid sponges was collected from Silurian sandstones at the top of the La Chilca Formation, cropping out at Cerro del Fuerte, 20 km east of Jáchal, in the San Juan Precordillera of west‐central Argentina. This is the first occurrence of a Silurian spicule fauna recorded at higher palaeolatitudes from Argentina and the entire South American part of Gondwana. The spicules were extracted by means of formic acid treatment from sandstones of the uppermost part of the La Chilca Formation, which ranges in age from the late Hirnantian to Llandovery, based on graptolites, brachiopods and conodonts. The spicule association is composed only of scarce siliceous hexactine‐based spicules which cannot be attributed to any specific hexactinellid taxon. The fragmentary preservation of this allochthonous sponge assemblage points toward preburial transport. These spicules represent the only microfauna found in the uppermost sandstones. Macrofossils are absent. No conodonts have been recovered in these levels. Two interpretations on the spicules of the Precordillera can be argued: (a) that those early Silurian hexactinellids could have occurred in quartz sandstones of the shore‐facies to off‐shore transitional associations, in the upper La Chilca Formation, or (b) that these sponges flourished in mainly calcareous shales in quiet deep‐water conditions, and that their fragile spicules were removed and deposited by oceanic currents, on the top of the outer‐shelf sand bars.Both hypotheses on the palaeoenvironmental origin of these spicules are substantially different, but the scarcity of spicules does not allow a more precise interpretation. The discovery of these hexactinellid spicules provides a new perspective on Silurian sponge occurrence and distribution for the Argentine Precordillera. Copyright © 2011 John Wiley & Sons, Ltd.