Wilms' tumor‐specific methylation pattern in 11p13 detected by PFGE
Copyright policy )Wilms' tumor‐specific methylation pattern in 11p13 detected by PFGE
AbstractThe analysis of 2,550 kb from 11 p 13 in Wilms' tumor (WT) material revealed two regions that differed significantly in their methylation between tumor and normal tissue. In WT a hypomethylated area defined by an Nrul and Mlul recognition site 100–150 kb centromeric of the WT gene WTI (site A) and hypermethylation defined by an Nrul and Sacll site 100 kb telomeric of the WTI gene were found (site B). The degree of methylation in region B varied between 20 and 100% in the different samples; the highest level was observed in tumors without preoperative chemotherapy. The CpG island 5′ of the WTI gene was partially methylated in 2/29 tumors analyzed. The methylation state of regions A and B could reflect the normal pattern present in a subset of embryonal kidney cells, from which WT develops.
- Institut für Humangenetik Germany
- Heidelberg University Germany
Genes, Wilms Tumor, Chromosomes, Human, Pair 11, Zinc Fingers, DNA, Neoplasm, Blotting, Northern, Methylation, Wilms Tumor, Kidney Neoplasms, Electrophoresis, Gel, Pulsed-Field, DNA-Binding Proteins, Humans, WT1 Proteins, Repetitive Sequences, Nucleic Acid
Genes, Wilms Tumor, Chromosomes, Human, Pair 11, Zinc Fingers, DNA, Neoplasm, Blotting, Northern, Methylation, Wilms Tumor, Kidney Neoplasms, Electrophoresis, Gel, Pulsed-Field, DNA-Binding Proteins, Humans, WT1 Proteins, Repetitive Sequences, Nucleic Acid
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