Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)
Copyright policy )Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)
AbstractIntravenous leiomyomatosis (IVL) is a rare smooth‐muscle proliferation that is of special interest because of its quasi‐malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15‐qter and/or loss of 14q24‐qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation. © 2003 Wiley‐Liss, Inc.
- Brigham and Women's Faulkner Hospital United States
- University of Manchester United Kingdom
- University of Manchester United Kingdom
- Harvard University United States
Adult, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 12, Leiomyoma, Pair 14, Translocation, Chromosomes, Translocation, Genetic, Vascular Neoplasms, Genetic, Leiomyomatosis, Cytogenetic Analysis, Uterine Neoplasms, Journal Article, Pair 12, Humans, Female, Human
Adult, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 12, Leiomyoma, Pair 14, Translocation, Chromosomes, Translocation, Genetic, Vascular Neoplasms, Genetic, Leiomyomatosis, Cytogenetic Analysis, Uterine Neoplasms, Journal Article, Pair 12, Humans, Female, Human
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