AbstractNon‐orthogonal multiple access (NOMA) technology is a key technology of the future cellular mobile communication system. It provides services for users under different channel conditions through signal superposition transmission and spectrum multiplexing. Pattern division multiple access (PDMA) is a new NOMA technology based on the overall optimization of multi‐user communication system. Since the performance of PDMA mainly depends on the gain of the pattern matrix, we propose a design scheme of uplink PDMA pattern matrix for ultra‐reliable low latency communication (uRLLC). For the interference between users is a common problem in NOMA system, first, we use poly complementary sequence (PCS) as the spread codebook to spread the PDMA transmission signal and reduce interference. Meanwhile, an uplink power control scheme is proposed. It allocates wireless resources reasonably by jointly considering the interference between users and resource blocks within users (JUR), the corresponding outage probability formula is also derived. Simulation results show that compared with the previous researches, the pattern matrix design scheme and JUR power control scheme proposed in this article have greatly improved the transmission performance. The addition of PCS spread spectrum technology can significantly reduce the block error rate and outage probability.