AbstractA performance‐based design procedure is proposed for seismically isolated bridges with/without supplemental energy dissipation devices. Considering multiple performance levels (PLs), the proposed method initially identifies the critical hazard level and “near‐optimal” alternatives of the isolation system. Both performance and economy are evaluated based on the inelastic response of reduced‐degree‐of‐freedom (RDOF) isolation and energy dissipation systems. Nonlinear response history analysis (NLRHA) of the multi‐degree‐of‐freedom (MDOF) system is employed in successive design steps, corresponding to different PLs, to refine the design solution through the control of a broad range of material strains and deformations. The above characteristics aim to deliver a rigorous and broadly applicable design method that reduces the high computational effort characterising complex design frameworks, while addressing identified deficiencies of alternative displacement‐based methods. The efficiency of the proposed design methodology is demonstrated by applying it to an actual bridge that was previously designed for ductile behaviour. Alternative isolation and energy dissipation schemes are investigated. Assessment of the design through NLRHA reveals in all cases enhanced seismic performance and cost reduction in the substructure design, thus rendering base‐isolation an appealing design alternative.