AbstractThis study examines the efficacy of using seismic isolation to favorably influence the seismic response of cable‐stayed bridges subjected to near‐field earthquake ground motions. In near‐field earthquake ground motions, large amplitude spectral accelerations can occur at long periods where many cable‐stayed bridges have significant structural response modes. This combination of factors can result in large tower accelerations and base shears. In this study, lead–rubber bearing seismic isolators were modeled for three cable‐stayed bridges, and three cases of isolation were examined for each bridge. The nine isolated bridge configurations, plus three non‐isolated configurations as references, were subjected to near‐field earthquake ground motions using three‐dimensional time‐history analyses. Introduction of a small amount of isolation is shown to be very beneficial in reducing seismic accelerations and forces while at the same time producing only a modest increase in the structural displacements. There is a low marginal benefit to continue to increase the amount of isolation by further lengthening the period of the structure because structural forces and accelerations reduce at a diminishing rate whereas structural displacements increase substantially. In virtually all cases the base shears in the isolated bridges were reduced by at least 50several instances by up to 80individual near‐field records showed large variability from one record to the next, with coefficients of variation about the mean as large as 50assessing the characteristics of near‐field ground motion for use in isolation design of cable‐stayed bridges. Copyright © 2003 John Wiley & Sons, Ltd.