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Ubiquitin in the immune system

descriptionPublicationkeyboard_double_arrow_right Article , Conference object , Other literature type 27 Dec 2013 United Kingdom English Publisher:Springer Science and Business Media LLCJournal:EMBO reports, volume 15, pages 322-322 (issn: 1469-221X, eissn: 1469-3178, Copyright policy )Funded by:SNSF | Qui châtie bien… Mauvais ..., WT | unidentified, SNSF | Role of linear ubiquityla... +1 projects
Authors: Zinngrebe Julia; Montinaro Antonella; Peltzer Nieves; Walczak Henning;

doi: 10.1002/embr.201470030 , 10.1002/embr.201338025

pmid: 24375678

pmc: PMC4303447

Ubiquitin in the immune system

Abstract

Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance.

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United Kingdom
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Keywords

Tumor Necrosis Factor-alpha, Ubiquitin, autoimmunity, Toll-Like Receptors, Ubiquitination, Reviews, Immunity, Innate, Self Tolerance, E3 ligases, inflammation, LUBAC, Host-Pathogen Interactions, Proteolysis, Animals, Humans, DUBs, Adaptor Proteins, Signal Transducing, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 196
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
196
Top 1%
Top 10%
Top 1%
Green
gold
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