Sensing the hybrid—a novel PAMP for TLR9

descriptionPublicationkeyboard_double_arrow_right Article 12 Feb 2014 English Publisher:Springer Science and Business Media LLCJournal:The EMBO Journal, volume 33, pages 529-530 (issn: 0261-4189, eissn: 1460-2075,

Copyright policy )Funded by:NNF | unidentified, NHMRC | Hypertonic saline (HTS) i...

Authors: Søren B, Jensen; Søren R, Paludan;

doi: 10.1002/embj.201487747

pmid: 24521669

pmc: PMC3989645

Sensing the hybrid—a novel PAMP for TLR9

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Abstract

The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen-associated molecular patterns (PAMP). Toll-like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons. In this issue of The EMBO Journal, Rigby et al identify RNA-DNA hybrids as a novel PAMP specifically recognized by TLR9 in dendritic cells.

Related Organizations

Aarhus University
Denmark

Keywords

Toll-Like Receptor 9, Models, Immunological, Nucleic Acid Heteroduplexes, Animals, Humans, Dendritic Cells, Immunity, Innate, Signal Transduction

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