Mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1979 English Publisher:WileyJournal:Environmental Mutagenesis, volume 1, pages 277-282 (issn: 0192-2521, eissn: 1930-238X,

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Authors: W Z, Whong; N D, Speciner; G S, Edwards;

doi: 10.1002/em.2860010310

pmid: 399911

Mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite

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Abstract

AbstractIn vivo nitrosation of dimethylamine by nitrite was measured with an intrahepatic host‐mediated mutagenicity assay using Salmonella typhimurium as the detecting organism. It was possible to detect the product, N‐nitrosodimethylamine, at much lower doses with this system than with previously reported in vivo systems. This and other improvements made it possible to detect the formation of nitrosodimethylamine from relatively low levels of gavaged precursors.

Keywords

Salmonella typhimurium, Diethylamines, Mutagenicity Tests, Dimethylnitrosamine, Rats, Mice, Liver, Animals, Biotransformation, Nitrites, Mutagens

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