A 33 bp minisatellite repeat upstream of the ‘mutated in colon cancer’ gene at chromosome 5q21

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1998 English Publisher:WileyJournal:ELECTROPHORESIS, volume 19, pages 1,362-1,365 (issn: 0173-0835, eissn: 1522-2683,

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Authors: P, Bugert; C, Kenck; G, Kovacs;

doi: 10.1002/elps.1150190827

pmid: 9694282

A 33 bp minisatellite repeat upstream of the ‘mutated in colon cancer’ gene at chromosome 5q21

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Abstract

AbstractWe have found a 33 bp minisatellite repeat in the 5′‐flanking region of the mutated in colon cancer (MCC) gene at chromosome 5q21. Southern blot experiments demonstrated the locus specificity of the repeat. The number of repeat units varied between 5 and 11 with a heterozygosity of 0.56. The sequence 5′‐AGG AGT GTG AAT GGG GCA TAG TGA ATG AGG GGA‐3′ of the repeat units does not match the consensus sequence of chi‐related minisatellites. The minisatellite is not expressed as part of a gene transcription unit. However, it can be used as a tool for the detection of allelic changes at chromosome 5q21 on standard agarose gels.

Related Organizations

Heidelberg University
Germany

Keywords

Polymorphism, Genetic, Base Sequence, Tumor Suppressor Proteins, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Proteins, Colonic Neoplasms, Chromosomes, Human, Pair 5, Humans, Microsatellite Repeats

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