
pmid: 17972354
Invariant natural killer T (iNKT) cells as we know them today are a unique subset of mature T cells co-expressing a semi-invariant Valpha14/Vbeta8 TCR and surface markers characteristic of NK cells. The semi-invariant TCR on iNKT cells recognizes glycolipids bound to monomorphic CD1d molecules, leading to rapid cytokine production. The purpose of this historical perspective is to describe how a series of seemingly unrelated findings in the late 1980s and early 1990s crystallized in the discovery of iNKT cells. The story is told from a personal viewpoint, with a particular effort to place both breakthroughs and misinterpretations in the context of their era.
Cytotoxicity, Immunologic, Killer Cells, Natural, T-Lymphocyte Subsets, Allergy and Immunology, T-Lymphocytes, Receptors, Antigen, T-Cell, Animals, Humans, History, 20th Century
Cytotoxicity, Immunologic, Killer Cells, Natural, T-Lymphocyte Subsets, Allergy and Immunology, T-Lymphocytes, Receptors, Antigen, T-Cell, Animals, Humans, History, 20th Century
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