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Single nucleotide polymorphisms as a prerequisite for autoantigens

descriptionPublicationkeyboard_double_arrow_right Article 28 Jan 2005Publisher:WileyJournal:European Journal of Immunology, volume 35, pages 371-378 (issn: 0014-2980, eissn: 1521-4141,

Authors: Sarah Luginbühl; Beda M. Stadler; Diana Arnold; Sara Frieden; Michael B. Stadler;

doi: 10.1002/eji.200425481

pmid: 15627977

Single nucleotide polymorphisms as a prerequisite for autoantigens

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Abstract

AbstractIt is still elusive why certain self proteins induce an autoimmune response. One immunological hypothesis is that only modified or altered self‐proteins may become a target. Thus, we asked whether such alterations may actually be genetic polymorphisms that can be revealed by analyzing sequence variability in the known human autoantigens. Indeed, we found autoantigens to contain significantly more single nucleotide polymorphisms (SNP) than other human genes do. Our finding may offer an explanation for autoimmune responses through allogeneic exposure. Besides other contributing factors in autoimmunity, SNP may represent an essential prerequisite for the primary induction of an autoimmune response.See accompanying Commentary: http://dx.doi.org/10.1002/eji.200425888

Related Organizations

University of Bern
Switzerland

Keywords

Molecular Sequence Data, Chromosome Mapping, Autoimmunity, Autoantigens, Polymorphism, Single Nucleotide, Autoimmune Diseases, Epitopes, Self Tolerance, Multigene Family, Databases, Genetic, Humans, Amino Acid Sequence

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