IL‐1 acts on antigen‐presenting cells to enhance the in vivo proliferation of antigen‐stimulated naive CD4 T cells via a CD28‐dependent mechanism that does not involve increased expression of CD28 ligands
Copyright policy )IL‐1 acts on antigen‐presenting cells to enhance the in vivo proliferation of antigen‐stimulated naive CD4 T cells via a CD28‐dependent mechanism that does not involve increased expression of CD28 ligands
AbstractThe basis of the adjuvant effect of IL‐1 on the clonal expansion of Ag‐specific CD4 T cells was measured in vivo using the TCR transgenic T cell adoptive transfer method. Injection ofAg plus IL‐1 caused naive CD4 T cells to proliferate to a greater extent than did injection of Ag alone. The T cells had to express CD28 to experience the beneficial effect of IL‐1 whereas the hosthad to express the type I IL‐1R, raising the possibility that IL‐1's adjuvant properties were related to induction of CD28 ligands on APC. Surprisingly, however, expression of CD28 ligands on DC and B cells was not affected by IL‐1. Therefore, the adjuvant properties of IL‐1 depend on a basal level of CD28 signaling but cannot be explained by enhanced CD28 signaling due to CD28 ligand induction.
- University of Minnesota Morris United States
- University of Minnesota United States
CD4-Positive T-Lymphocytes, Lipopolysaccharides, Receptors, Antigen, T-Cell, Antigen-Presenting Cells, Mice, Transgenic, Flow Cytometry, Lymphocyte Activation, Adoptive Transfer, Mice, CD28 Antigens, Animals, Antigens, Interleukin-1
CD4-Positive T-Lymphocytes, Lipopolysaccharides, Receptors, Antigen, T-Cell, Antigen-Presenting Cells, Mice, Transgenic, Flow Cytometry, Lymphocyte Activation, Adoptive Transfer, Mice, CD28 Antigens, Animals, Antigens, Interleukin-1
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