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Is the antibody response specific?

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1986 English Publisher:WileyJournal:European Journal of Immunology, volume 16, pages 557-562 (issn: 0014-2980, eissn: 1521-4141,

Authors: Howard M. Etlinger; Howard M. Etlinger;

doi: 10.1002/eji.1830160517

pmid: 2422046

Is the antibody response specific?

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Abstract

AbstractIntroduction of heterologous immunoglobulin (Ig) or red blood cells into mice results in an increased production of Ig and immunogen‐reactive antibody. Since the increase in both total Ig and specific antibody is similar, it is concluded that the antibody response is specific. This result, which contrasts with those of previous studies in which the production of large amounts of nonspecific Ig was reported, suggests that in vivo T‐dependent B cell activation and differentiation to plasma cells requires the presence of immunogen and linked recognition.

Related Organizations

National Institute of Health
Pakistan
National Institute of Allergy and Infectious Diseases
United States
Roche (Switzerland)
Switzerland
National Institutes of Health
United States

Keywords

B-Lymphocytes, Erythrocytes, Age Factors, Dose-Response Relationship, Immunologic, Cell Differentiation, Lymphocyte Activation, Antibodies, Mice, Antibody Specificity, Immunoglobulin G, Antibody Formation, Animals, gamma-Globulins

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