Presenilin 1 is essential for cardiac morphogenesis
Copyright policy )Presenilin 1 is essential for cardiac morphogenesis
AbstractPresenilin 1 (PS1) is the gene responsible for the development of early‐onset familial Alzheimer's disease. PS1‐deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1‐deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ventricle, and stenosis in the pulmonary artery. Immunohistochemistry using anti‐PS1 antibody revealed the prominent expression of PS1 in mesenchymal cells at the septal area of the wild‐type heart. These results suggest that PS1 may play an essential role in heart development. Developmental Dynamics 230:795–799, 2004. © 2004 Wiley‐Liss, Inc.
Heterozygote, Time Factors, Octoxynol, Myocardium, Detergents, Membrane Proteins, Heart, Mice, Transgenic, Immunohistochemistry, Mesoderm, Mice, Inbred C57BL, Mice, Phenotype, Mutation, Presenilin-1, Animals
Heterozygote, Time Factors, Octoxynol, Myocardium, Detergents, Membrane Proteins, Heart, Mice, Transgenic, Immunohistochemistry, Mesoderm, Mice, Inbred C57BL, Mice, Phenotype, Mutation, Presenilin-1, Animals
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