AbstractThis paper introduces the establishment of deep underground infrastructure for science and engineering research. First, the representative deep underground research laboratories and facilities in the world and their functions were summarized and reviewed. Then, the plan and service target of China Yulong Lake Laboratory were proposed for the storage of resources and energy, as well as the sealing of hazardous waste in deep underground space. On this basis, this paper reveals how the facility addresses its key scientific issue on “The law of fluid matter migration in deep underground space” and engineering significance. Finally, the construction progress of the facility components was demonstrated in details. As is hoped, this paper would provide useful reference to the deep underground research community; meanwhile, international collaboration on deep underground research is highly welcome.