Genome‐wide association studies (GWAS): impact on elucidating the aetiology of diabetes

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2011 English Publisher:WileyJournal:Diabetes/Metabolism Research and Reviews, volume 27, pages 685-696 (issn: 1520-7552, eissn: 1520-7560,

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Authors: Hakon, Hakonarson; Struan F A, Grant;

doi: 10.1002/dmrr.1221

pmid: 21630414

Genome‐wide association studies (GWAS): impact on elucidating the aetiology of diabetes

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Abstract

AbstractIt has proven to be challenging to isolate the genes underlying the genetic components conferring susceptibility to type 1 and type 2 diabetes. Unlike previous approaches, ‘genome‐wide association studies’ have extensively delivered on the promise of uncovering genetic determinants of complex diseases, with a number of novel disease‐associated variants being largely replicated by independent groups. This review provides an overview of these recent breakthroughs in the context of type 1 and type 2 diabetes, and outlines strategies on how these findings will be applied to impact clinical care for these two highly prevalent disorders. Copyright © 2011 John Wiley & Sons, Ltd.

Related Organizations

University of Pennsylvania
United States
Children's Hospital of Philadelphia
United States

Keywords

Diabetes Mellitus, Type 2, Humans, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study

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