The effect of butylated hydroxyanisole and butylated hydroxytoluene on behavioral development of mice

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1974 English Publisher:WileyJournal:Developmental Psychobiology, volume 7, pages 343-350 (issn: 0012-1630, eissn: 1098-2302,

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Authors: J D, Stokes; C L, Scudder;

doi: 10.1002/dev.420070411

pmid: 4472726

The effect of butylated hydroxyanisole and butylated hydroxytoluene on behavioral development of mice

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Abstract

AbstractThe chronic ingestion of .5% butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) by pregnant mice and their offspring resulted in a variety of behavioral changes. Compared to controls, BHA‐treated offspring showed increased exploration, decreased sleeping, decreased self‐grooming, slower learning, and a decreased orientation reflex. BHT‐treated offspring showed decreased sleeping, increased social and isolation‐induced aggression, and a severe deficit in learning.

Related Organizations

Loyola University Chicago
United States

Keywords

Brain Chemistry, Male, Behavior, Animal, Butylated Hydroxyanisole, Anisoles, Butylated Hydroxytoluene, Motor Activity, Grooming, Models, Biological, Aggression, Cresols, Mice, Animals, Newborn, Conditioning, Psychological, Avoidance Learning, Exploratory Behavior, Animals, Humans, Female, Maternal-Fetal Exchange

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