AbstractThis study explored the use of amino acid‐based ionic liquids to facilitate the conversion of carbon dioxide (CO2) into methanol through catalytic hydrogenation. Combining tetrabutylammonium L‐argininate (TBA⋅Arg) with the ruthenium Ru‐MACHO‐BH complex allowed achieving significant yields of methanol under optimized conditions, with a turnover number (TON) up to 700. By systematically varying key reaction parameters, we demonstrated that the TBA⋅Arg ionic liquid promotes the efficient hydrogenation pathway leading to methanol formation, thus offering a sustainable approach to CO2 valorization. These findings underscore the potential of amino acid‐based ionic liquids in catalyzing the transformation of CO2 into valuable chemicals, contributing to carbon mitigation efforts.