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ChemSusChem
Article . 2019 . Peer-reviewed
License: CC BY
Data sources: Crossref
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ChemSusChem
Article
License: CC BY
Data sources: UnpayWall
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PubMed Central
Other literature type . 2019
Data sources: PubMed Central
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UCL Discovery
Article . 2019
Data sources: UCL Discovery
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A Ball‐Milling‐Enabled Reformatsky Reaction

Authors: Qun Cao; Roderick T. Stark; Ian A. Fallis; Duncan L. Browne;

A Ball‐Milling‐Enabled Reformatsky Reaction

Abstract

AbstractAn operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre‐activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source.

Country
United Kingdom
Related Organizations
Keywords

SOLVENT, Science & Technology, Multidisciplinary, BETA-UNSATURATED KETONES, TERTIARY ALKYLZINC BROMIDES, ORGANIC-SYNTHESIS, MECHANOCHEMICAL SYNTHESIS, Communications, ALPHA, Chemistry, reformatsky reaction, ZINC, Physical Sciences, Science & Technology - Other Topics, organozinc formation, REAGENTS, ball milling, ENHANCED AIR, mechanochemistry, BETA-AMINO ESTERS, Green & Sustainable Science & Technology, POLYMORPH

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    64
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
64
Top 1%
Top 10%
Top 1%
Green
hybrid