
AbstractAn operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre‐activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source.
SOLVENT, Science & Technology, Multidisciplinary, BETA-UNSATURATED KETONES, TERTIARY ALKYLZINC BROMIDES, ORGANIC-SYNTHESIS, MECHANOCHEMICAL SYNTHESIS, Communications, ALPHA, Chemistry, reformatsky reaction, ZINC, Physical Sciences, Science & Technology - Other Topics, organozinc formation, REAGENTS, ball milling, ENHANCED AIR, mechanochemistry, BETA-AMINO ESTERS, Green & Sustainable Science & Technology, POLYMORPH
SOLVENT, Science & Technology, Multidisciplinary, BETA-UNSATURATED KETONES, TERTIARY ALKYLZINC BROMIDES, ORGANIC-SYNTHESIS, MECHANOCHEMICAL SYNTHESIS, Communications, ALPHA, Chemistry, reformatsky reaction, ZINC, Physical Sciences, Science & Technology - Other Topics, organozinc formation, REAGENTS, ball milling, ENHANCED AIR, mechanochemistry, BETA-AMINO ESTERS, Green & Sustainable Science & Technology, POLYMORPH
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