Transcriptome‐Wide Association Studies (TWAS): Methodologies, Applications, and Challenges
Copyright policy )Transcriptome‐Wide Association Studies (TWAS): Methodologies, Applications, and Challenges
AbstractTranscriptome‐wide association study (TWAS) methodologies aim to identify genetic effects on phenotypes through the mediation of gene transcription. In TWAS, in silico models of gene expression are trained as functions of genetic variants and then applied to genome‐wide association study (GWAS) data. This post‐GWAS analysis identifies gene‐trait associations with high interpretability, enabling follow‐up functional genomics studies and the development of genetics‐anchored resources. We provide an overview of commonly used TWAS approaches, their advantages and limitations, and some widely used applications. © 2024 Wiley Periodicals LLC.
- Vanderbilt University Medical Center United States
Phenotype, Quantitative Trait Loci, Computer Simulation, Transcriptome, Genome-Wide Association Study
Phenotype, Quantitative Trait Loci, Computer Simulation, Transcriptome, Genome-Wide Association Study
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