The levels of methadone in the plasma in methadone maintenance
Copyright policy )The levels of methadone in the plasma in methadone maintenance
The time course of methadone in the plasma of 5 methadone maintenance subjects receiving a single daily oral dose of 100 or 120 mg. has been determined. The predose mean plasma level of methadone was 0.48 fig per milliliter. The peak plasma level occurred at 4 hours with an average value of 0.86 fig per milliliter. This level slowly declined so that 24 hours after administration the mean plasma level had reached a value (0.46 fig per milliliter) approximately equal to the predose level. The mean apparent half‐life of methadone in these sub;ects was 25 hours. Data on the renal clearance of methadone indicate that the drug is partially reabsorbed by the kidney and that this reabsorption is pH dependent.
- Cornell University United States
Adult, Male, Time Factors, Substance-Related Disorders, Administration, Oral, Humans, Hydrogen-Ion Concentration, Methadone, Half-Life
Adult, Male, Time Factors, Substance-Related Disorders, Administration, Oral, Humans, Hydrogen-Ion Concentration, Methadone, Half-Life
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