Allergic reaction to procarbazine

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1972 English Publisher:WileyJournal:Clinical Pharmacology & Therapeutics, volume 13, pages 573-574 (issn: 0009-9236, eissn: 1532-6535,

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Authors: J J, Lokich; W C, Moloney;

doi: 10.1002/cpt1972134573

pmid: 4261284

Allergic reaction to procarbazine

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Abstract

Procarbazine is a methylhydrazine derivative used in the treatment of Hodgkin's disease. Two patients who developed allergic hypersensitivity reactions, one with near‐fatal allergic pneumonitis and one with allergic dermititis are described. A mechanism of sensitization is suggested, and the importance of awareness of this reaction and the need for early lung biopsy are stressed.

Keywords

Adult, Male, Rhinitis, Allergic, Seasonal, Antineoplastic Agents, Pneumonia, Middle Aged, Benzoates, Hodgkin Disease, Drug Hypersensitivity, Procarbazine, Humans, Drug Eruptions

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