Latency of cough response as a measure of antitussive agents

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1967 English Publisher:WileyJournal:Clinical Pharmacology & Therapeutics, volume 8, pages 374-380 (issn: 0009-9236, eissn: 1532-6535,

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Authors: B, Calesnick; J A, Christensen;

doi: 10.1002/cpt196783374

pmid: 5338381

Latency of cough response as a measure of antitussive agents

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Abstract

The cough reflex was stimulated in selected healthy male subjects with a single nebulized threshold dose of citric acid. The essential components of the method were deep inhalation by the subjects and the measurement of the required time to elicit the cough reflex. Prolongation of latency was used as a measure of antitussive action. With the use of this parameter, a dose‐response curve was obtained for codeine and dextromethorphan.

Related Organizations

Drexel University
United States

Keywords

Adult, Male, Carbon Isotopes, Clinical Trials as Topic, Codeine, Middle Aged, Phenanthrenes, Placebos, Antitussive Agents, Cough, Humans, Citrates, Aged

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