Pharmacometrics (PMX) in Africa has transitioned from foundational capacity‐building to job creation, scientific leadership, regulatory influence, and health innovation. To accelerate this progress, the 2025 Pharmacometrics Africa Conference (PMXAC‐2025) convened key stakeholders to consolidate the continental PMX community, review progress in local capacity, and define priorities for African‐led quantitative pharmacology and regulation. Held as a hybrid event in Kampala, Uganda, PMXAC‐2025 featured plenary sessions, technical workshops, and poster presentations. A pre‐conference nlmixr2 workshop strengthened open‐source modeling expertise, while eight presentations and 32 posters facilitated discussions on capacity development, regulatory integration, and methodological innovation. The conference brought together 108 delegates, including 40 online participants from 14 countries (six African), reflecting strong global engagement. Regulatory representation (4.6%) demonstrated growing interdisciplinary collaboration. Sessions highlighted PMX as central to evidence‐based healthcare, with applications in regulatory harmonization, patient‐centered dosing, and equitable access. Presentations on model‐based bioequivalence (MBBE), physiologically based pharmacokinetic (PBPK) modeling for safely extrapolating drug exposure in complex, understudied populations such as pregnant women and children, and model‐based meta‐analysis (MBMA) illustrated data‐driven solutions for resource‐limited settings. Emphasis on open‐source tools reinforced technical equity, while career discussions promoted mentorship and cross‐border collaboration. A closing panel outlined eight priorities for sustained progress, including funding, leadership, and integrated multi‐sector partnerships. PMXAC‐2025 signaled Africa's transition toward PMX self‐reliance and innovation, uniting continental and diaspora experts, advancing open science, and setting a roadmap for sustainable, model‐informed drug development across the continent. To sustain this momentum, establishing PMXAC‐2025 as a regular annual event was strongly recommended.