PharmVar GeneFocus: CYP3A5

descriptionPublicationkeyboard_double_arrow_right Article 29 Mar 2022 United States English Publisher:WileyJournal:Clinical Pharmacology & Therapeutics, volume 112, pages 1,159-1,171 (issn: 0009-9236, eissn: 1532-6535,

Copyright policy )Funded by:VR | unidentified, NIH | Implementing genomic medi..., CIHR | unidentified +4 projects

Authors: Rodriguez-Antona, Cristina; Savieo, Jessica L.; Lauschke, Volker M.; Sangkuhl, Katrin; Drögemöller, Britt I.; Wang, Danxin; van Schaik, Ron H. N.; +8 Authors

doi: 10.1002/cpt.2563

pmid: 35202484

pmc: PMC9399309

handle: 1805/40785 , 1805/40708

PharmVar GeneFocus: CYP3A5

- Summary
- Subjects
- Metrics

Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus impacts the metabolism of several clinically important drugs, including the immunosuppressants tacrolimus, sirolimus, cyclosporine, and the benzodiazepine midazolam. Variable CYP3A5 activity is of clinical importance regarding tacrolimus metabolism. This GeneFocus provides a CYP3A5 gene summary with a focus on aspects regarding standardized nomenclature. In addition, this review also summarizes recent changes and updates, including the retirement of several allelic variants and provides an overview of how PharmVar CYP3A5 star allele nomenclature is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Country

United States

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Keywords

Genotype, Pharmacogene Variation Consortium (PharmVar), CYP3A5 gene, Tacrolimus, Polymorphic, Pharmacogenetics, Cyclosporine, Humans, Cytochrome P-450 CYP3A, Catalog, Immunosuppressive agents, Immunosuppressive Agents

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